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Therefore, a study showed a high level of preservation of global metabolic flux with aging in C57BL/6J mice, although plasma and tissue metabolite levels varied moderately (Jankowski et al., 2025)

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[9] The European Food Safety Authority (EFSA) also confirms that absorption through oral route drops significantly when doses exceed 1-2 mcg, meaning high-dose tablets rely mostly on passive absorption, which is inconsistent
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