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In diseases where amino-acid metabolizing enzymes are dysfunctional or absent (e.g., propionic acidemia and methylmalonic acidemias characterized by neurological symptoms, muscle weakness and low energy) C3 accumulates, and higher blood levels are used as a screening tool

The carnitine shuttle system is a key regulator of ferroptosis in cancer cells, and dysfunction of the carnitine cycle in general can influence tumorigenesis and progression of the disease by altering intracellular oxidative and inflammatory status or regulating tumour metabolism

[146] In 2006, Santos received a star on the Philippines Walk of Fame

Short-chain acylcarnitines (acetyl- and butyrylcarnitine) are hydrolysed to l-carnitine and a short-chain fatty acid by the esterase HocS (Meadows & Wargo, 2013), while the medium- and long-chain acylcarnitine hydrolase(s) has not yet been identified