glutathione phase 1 detoxification Drug metabolism Glutathione-Mediated Conjugation of Anticancer Drugs:

A common pathway affecting all these risk factors involves a low measure of reduced glutathione (i.e., GSH) level (Khanfar and Al Qaroot, 2020

In patients with diabetes, persistent hyperglycemia and IR induce ERS and impair Ca 2+ handling

Without efficient Phase II Detoxification, even substances that have undergone initial processing in Phase I could remain harmful or become more reactive, leading to cellular damage and systemic health issues

Hortu et al

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