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The combined effects of these blood-derived proteins lead to a vicious cycle of inflammation and oxidative stress, further accelerating neurodegenerative disease progression [54,63,64]

Protocatechuic acid promotes the neuronal differentiation and facilitates survival of phenotypes differentiated from cultured neural stem and progenitor cells

RVG29, a new type of RMT-targeting peptide, can specifically recognize nicotinic acetylcholine receptors, which not only show high expression in ECs but also in astrocytes, microglia, and dopaminergic neurons

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It was also funded by the European Regional Development Fund through the Programa Operacional Regional do Centro (Centro 2020)Sistema de Apoio Investigao Cientfica e TecnolgicaProgramas Integrados de IC&DT, Centro-01-0145-FEDER-000019-C4-Centro de Competncias em Cloud Computing