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Metabolomics study of urine in autism spectrum disorders using a multiplatform analytical methodology

Also, the upregulation of UCP2 increases the concentration in hypoxia-inducible factor 1-alpha (HIF-1), which reduces PPAR and favors lipid depots

ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis

Deprotonation of GSH contributes significantly to the catalytic activity of GST A1-1 (Ibarra et al., 2003)

By wrapping the glutathione in this protective shell, we allow it to bypass the harsh digestive process