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High-resolution MS was performed using electrospray ionization and time-of-flight mass analysis

Metabolites produced by skin commensals activate AHRs, thus sustaining epidermal cell differentiation

This process facilitated the generation of context-specific models for each cell or gene expression dataset

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Abbreviations ALT Alanine aminotransferase AST Aspartate aminotransferase BMI Body mass index CAP Controlled attenuation parameter FBS Fasting blood sugar HbA1c hemoglobin A1c HDL High-density lipoprotein IRI Immunoreactive insulin LDL Low-density lipoprotein LSM Liver stiffness measurement NAFLD Nonalcoholic fatty liver disease NASH Nonalcoholic steatohepatitis NEFA Non-esterified fatty acid UMIN University Hospital Medical Information Network VCTE Vibration-controlled transient elastography Authors contributions Designed and coordinated the study: TK, YH, YS, and AN