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Herein, we uncovered the presence of the CD147/MCT1/LDHB complex in the mitochondria, and this complex was correlated with stemness potentials in lung metastatic tumors and CTCs of patients with breast cancer, contributing to tumor metastasis and poor clinical outcomes for patients

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Monoclonal anti-HMGB1 (high mobility group box chromosomal protein 1) antibody protection in two experimental arthritis models

doi: 10.1056/NEJMoa1615692 113 EurichDTMcAlisterFABlackburnDFMajumdarSRTsuyukiRTVarneyJet al

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These effects are associated with increased expression of the cyclin-dependent kinase inhibitors (CDKNs) p21 and p27, which are negative cell cycle regulators (Pandey et al., 2010)