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How your body adapts to metabolic changes during early treatment During the first few weeks, your body is learning to operate with lower circulating blood sugar and a different hormonal profile

Researchers think that this involves the vagus nerve .[ref] Vagus nerve interaction: A 2026 study showed that the GLP-1 receptor is expressed in the nodose neurons, which are the sensory cells that transmit information from the internal organs to the brainstem.[ref] GLP-1 Medications: Semaglutide, Tirzepatide, and Retatrutide Given GLP-1s powerful effects on appetite and glucose regulation, researchers developed synthetic medications that mimic its action

This dose is gradually increased over time to help reduce gastrointestinal side effects

Source: Mikhail et al., 2024

Despite a 100-lb weight loss, her depression at the time significantly worsened, leading to entry into a partial hospital program and switching of her antidepressant medications