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We hypothesise that mitochondrial biogenesis is disrupted in dominant glandular tissue cells owing to immune cell infiltration, resulting in decreased expression of PPARGC1A

[DOI] [PMC free article] [PubMed] [Google Scholar] (46).Zgurskaya HI, and Nikaido H (1999) Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli

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Iron overload, through ROS production, promotes cellular senescence in surrounding cells, thereby reinforcing a self-sustaining cycle of fibrosis, inflammation, and senescence [27]