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Direct Scavenging: Thanks to the active thiol group (-SH) on the cysteine residue, GSH acts as an electron donor

18 GST can induce cellular apoptosis in the setting of cellular stress by activating MAPK, MKK4, downstream JNK-signal components, and p38 kinase

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It lowers blood glucose levels by increasing glucose uptake in cells and reducing insulin secretion, which enhances insulin sensitivity (Samani et al., 2007)

Notably, Nrf2 translocates to the nucleus in ROS-sensitive cells, increases the antioxidant HO-1 levels, decreases the MDA levels, and increases the SOD and GSH activities (Xie et al., 2023

These side effects are typically a result of rapid infusion and can be helped by slowing the therapy, staying hydrated and fasting for a few hours beforehand