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It also stimulates the brain's appetite centers, promoting hyperphagia and contributing to the accumulation of fat in adipose tissue

And those statistics apply in randomized trials where they're directly compared head-to-head

Cross-organ sensitization, a well-documented mechanism in chronic pelvic and visceral pain disorders, may further explain why women with PCOS frequently report overlapping symptoms such as bladder pain, bowel discomfort, and generalized pelvic hypersensitivity, as nociceptive input from reproductive organs can sensitize shared spinal and pelvic afferent pathways (Majima et al., 2021

Severe diarrhea that you cannot control
