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While the etiology of NTD is multifactorial, some studies have found that blood concentrations of homocysteine or holo-transcobalamin to be lower in NTD-affected infants and mothers compared to non-affected controls (reviewed in 59)

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B12 is a water-soluble vitamin, so any amount that is not used by the body will simply be eliminated

daily for 14 days using a 1-mL syringe and a 23-gauge needle