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This process hinges on the ability of redox-active compounds to transfer electrons from GSH to oxygen in which ROS can trigger a cascade of events leading to airway and pulmonary inflammation, which can result in various adverse effects like cell and tissue damage 66

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However, under some conditions in which NAPQI is not effectively detoxified, usually in the case of paracetamol overdose, it causes severe damage to the liver

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10.1038/s41551-016-0011 197 WangC.WangJ.ZhangX.YuS.WenD.HuQ.et al (2018a)

This results in an overall decrease of the GSH/GSSG ratio