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General symptoms of thiamine deficiency include confusion, psychomotor retardation, impaired memory and cognitive function, and ataxia (, , , )

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Parkinsons disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled

Figure 2 Together, these results indicate that the treatment of sagittal brain slice cultures with 1 mM CPZ for 72 h induces acute demyelination as measured by a reduction in both MBP + and MOG + fluorescence intensity at 24 h