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Collectively, these pro-inflammatory cytokines can further exacerbate oxidative stress, creating a self-perpetuating cycle that sustains inflammation and tissue damage

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[DOI] [PubMed] [Google Scholar] Yang CS, Chou ST, Lin NN, Liu L, Tsai PJ, Kuo JS, Lai JS

Also, histidine 96 and histidine 111 (human PrP numbering) that are located outside the octarepeat region, are also actively involved in PrP-Cu 2+ binding (Snchez-Lpez et al., 2018)