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Restoration of such substrate adaptability is critical to preventing metabolic inflexibility, a hallmark of obesity and type 2 diabetes

Atherosclerosis: TMAO Activates ERS The ER, formed in continuity with the outer membrane of the nuclear envelope, plays a key role as a central eukaryotic membranous organelle and is responsible for the synthesis, folding, and maturation of membrane and secreted proteins, lipid biosynthesis, and calcium storage (67)

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it is also used to treat binge eating disorder in the form of lisdexamfetamine

The current evidence base nevertheless remains constrained, as mechanistic insights are derived largely from animal and in vitro studies, clinical investigations are typically small and cross-sectional, and well-powered longitudinal cohorts are scarce (Table S2)