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The transcriptional profile of the skin microbiota in HL414 was different from other healthy subjects after vitamin B12 supplementation To understand why subject HL414, not others in our healthy cohort, developed acne after vitamin B12 supplementation, we further investigated the specific bacterial transcriptional changes in HL414 compared to the other subjects 14 days after vitamin B12 supplementation

Niacin (B3): Encourages digestive well-being, enhances skin resilience, and aids in nerve maintenance

A contribution on acne medicamentosa (authors transl)]

Patient perspective The post-study Zoom calls revealed that all patients felt that they made significant improvements given the limitations of the study design and outcome measures

Bacterial overgrowth in the small intestine may similarly present with both symptoms

Safety, Regulation, and Quality Concerns From a regulatory perspective, AOD 9604 is not approved by the US FDA, and thus it has no approved medical indications