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The direct association between the microvascular density observed in the neoplastic tissue and tumour aggressiveness [7,8] , the identification of the angiogenic factors of the VEGF family [9,10] and the discovery that they are widely upregulated in human tumours [11-14] seemed to provide more evidences

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From the 3D structure of Glycine max ATPS1, the cysteine found at position 434 (corresponding to Cys435 in AtATPS1) seems exposed at the surface, but the effect of these different modifications on protein structure or activity is yet unexplored (Herrmann et al., 2015)