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We assume that this corresponds to the maximal analgesic effect of L838,417 experimentally observed ( Y max 31%, Fig

FUS/TLS was subcloned into pGEX6p-1 using BamHI and SalI sites to generate an N-terminal GST-fusion tag

A median duration of response of 10 months and a median progression-free survival of 6.8 months were also confirmed, in line with earlier Phase I results

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