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The progression of disease is slow and symptoms can take a few years to present

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In contrast, PPMS is defined by a gradual and continuous worsening of neurological function from disease onset, without distinct relapses or remissions

Palanimuthu D, Shinde SV, Somasundaram K, Samuelson AG (2013) In vitro and in vivo anticancer activity of copper bis(thiosemicarbazone) complexes