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Nutrients 10(10), 1398

In summary, the harsh metabolic landscape of the TME, characterized by nutrient competition, accumulation of immunosuppressive metabolites, and dysregulated lipid and amino acid metabolism, severely impairs the function and fate of infiltrating immune cells, ultimately promoting tumor immune evasion and progression

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Firstly, the investigators used the crystal-modified form of supplemental CoQ10, the bioavailability of which had been previously documented in human subjects [50]

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Anthocyanidins are flavones with different functional groups covalently linked to the three cycles