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Neurosci Bull 39:479490 Abdel-Haq R, Schlachetzki JCM, Boktor JC, et al (2022) A prebiotic diet modulates microglial states and motor deficits in -synuclein overexpressing mice

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Considering the close relationship between the neuronal survival environment and mitochondrial function and dynamics and the widespread reports of induction of neuronal death, including pyroptosis, apoptosis, and necroptosis, by imbalanced mitochondrial dynamics or mitochondrial dysfunction, it can be speculated that mitochondria may be a key factor in activating the unique PANoptosis pathway in neurons (Fricker et al., 2018)

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