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Baseline CRP 10 mg/L predicted higher odds of MELD-3 improvement, particularly in those with MELD-3 18, and decreases in CRP and NLR during follow-up were strongly associated with MELD-3 improvement, lower MELD, and substantially lower mortality

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However, of surprise, atpenin A5 showed a clear TOA effect against SARS-CoV-2 and RSV, even though it still exerted some antiviral activity when added 2 h post infection

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Several approaches are currently under investigation, including targeting and depleting B cells via CD19 in the early stages of the disease, simultaneously targeting B cells and memory plasma cells in later stages and refractory states, as well as targeting specific autoantigens through the chimeric autoantibody receptor (CAAR)