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doi:10.1172/JCI59903 Xu X, Yi M, Xiao C, et al

On the other hand, ROS induce the binding of Src homology 2 domain-containing phosphatase 1 (SHP1) to c-Src and the oxidation of c-Src and SHP-1, which lead to SHP-1 inactivation and activation of c-Src via phosphorylation of Tyr416, contributing to osteoclast survival and increasing bone loss (226)

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Tissuerelated and regenerative research models where structural integrity, matrix remodeling, or barrier properties are assessed