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The primary pathophysiology of DR encompasses various alterations induced by hyperglycemia, which include the thickening of the retinal capillary basement membrane, elevated retinal vascular permeability, retinal tissue ischemia, and the upregulation of multiple vasoactive substances, resulting in neovascularization [321]

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According to some research, low PLP levels may be a contributing factor in the development of diabetes, whereas other studies demonstrate that diabetes lowers PLP levels

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A randomized double-blind phase III trial comparing vintafolide (EC145) and pegylated liposomal doxorubicin (PLD/Doxil/Caelyx) in combination versus PLD in participants with platinum-resistant ovarian cancer (PROCEED) ( NCT01170650) Gynecol

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10.3389/fnmol.2017.00447 130 SeniorS

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Doycheva D1, Zierhut M, Blumenstock G, Stuebiger N, Deuter C

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[5] [6] Early life and education [edit] Greenfield was born in Lewiston, Idaho

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