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Shiro Bannai reported in 1977 that withdrawal of cystine (see Figure 1 for glossary of key terms in ferroptosis), the oxidized form of cysteine, caused cell death that correlated with glutathione depletion and could be prevented by treatment with vitamin E (Bannai et al., 1977)

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EMBO Rep 13, 10951101 (2012)

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In this review, we aim to discuss lipid peroxidation-derived 4-HNE and MDA in the progression of OA

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These models can be used to design personalized prevention and treatment strategies that address the specific molecular and biomechanical mechanisms underlying ACL injuries

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