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Shiro Bannai reported in 1977 that withdrawal of cystine (see Figure 1 for glossary of key terms in ferroptosis), the oxidized form of cysteine, caused cell death that correlated with glutathione depletion and could be prevented by treatment with vitamin E (Bannai et al., 1977)

EMBO Rep 13, 10951101 (2012)

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These shots are administered via intramuscular injection (often referred to as IM) so there is no gastrointestinal metabolism, which also allows for increased nutritional absorption

In this review, we aim to discuss lipid peroxidation-derived 4-HNE and MDA in the progression of OA
These models can be used to design personalized prevention and treatment strategies that address the specific molecular and biomechanical mechanisms underlying ACL injuries
