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PFIC5 PFIC5, paediatric cholestasis with jaundice, low GT, and elevated BAs, whose onset age ranges from a few days to a few weeks [48], is related to a deficiency of the BA receptor known as farnesoid X receptor (FXR) due to loss of function variant in the NR1H4 gene

Research underscores NACs effectiveness in boosting glutathione levels, thereby enhancing antioxidant defenses, supporting liver detoxification, and promoting overall cellular health [source]

If levels get too high or side effects occur, we might lower the dosage

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All participants received a treatment dosage once a week for 32 weeks

As an important intracellular antioxidant, it acts as a regulator of cellular redox state protecting cells from damage caused by lipid peroxides, reactive oxygen and nitrogen species, and xenobiotics