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The cerebrovascular anatomy has an endocranial and exocranial component that can be further divided into the anterior and posterior circulation based on the contribution of blood flow through the internal carotid arteries (ICAs) and vertebral arteries, respectively ( Blood-brain barrier (BBB), a part of the neurovascular unit (NVU), is a unique, dynamic, physical, and biochemical regulatory boundary/barrier which restricts and regulates the exchange of molecules, ions, and cells between the peripheral circulation and central nervous system (CNS) (Yang et al., 2019) and maintains cerebral homeostasis precisely as well (Winkler et al., 2011) thus protecting the CNS from inflammation, injury, and different types of diseases ( Disruption of BBB is associated with different neurological disorders for instance stroke, MS, epilepsy, Alzheimers disease, traumatic brain injury etc

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