glutathione conjugation xenobiotics Involvement of in the detoxification of and Glutathione conjugation - Sulfate uptake

Although it is not clear whether drugs exert hepatotoxic effects, PPAR may be involved in the hepatotoxic mechanism

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the cytosol and mitochondrial matrix have high GSH:GSSG ratios of approximately 100:1, whereas the ER has a substantially lower ratio of closer to 3:1 (Ribas et al., 2014)

Wang C, Li W, Wang H, Ma Y, Zhao X, Zhang X, et al

PPAR- Modulators as current and potential cancer treatments

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