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R., Brocato L., Manzato E., Berchio A., et al

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Of note, while we cannot completely exclude effects by parkin deficiency on de novo glutathione synthesis, we found no significant rise in mRNA levels of subunits for the rate-limiting enzyme, i.e., glutamate-cysteine ligase ( Gclm and Gclc ), nor did we see a consistent rise in total glutathione (GSH + 2GSSG) concentrations across the parkin-deficient-only model systems

Evidence that Metformin Exerts Its Anti-Diabetic Effects through Inhibition of Complex 1 of the Mitochondrial Respiratory Chain

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