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Funding This research was supported by the Natural Science Foundation of China (32202641, 32460819, 31960672), the Natural Science Foundation of Ningxia (2025AAC030558, 2025AAC040003), the Central Guidance on Local Science and Technology Development Fund (2024FRD05052) and the Key R & D projects in Ningxia Hui Autonomous Region (2024BBF01007 & 2023BCF01006)

Summary Multiple lines of evidence indicate that dysregulation of any of several components of the UPS, or mutations in genes that encode them, exacerbate AD progression and are deleterious to the recovery of function after SCI

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