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The label recommends considering a dose reduction of ganaxolone when initiating a UGT inhibitor

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10.3892/mmr.2019.9836 33 ChenP.NingL.QiuP.MoJ.MeiS.XiaC.et al (2019b)

So in simple terms, to obtain thiamine from TTFD the cells use up their reduced glutathione

The area will likely feel tender for a week or two
