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Under nutrient deprivation, HCC cells activate ketolysis to maintain energy supply, suppressing AMPK activity and inhibiting Tregs for rapid energy acquisition, HCC cells produce lactate via the Warburg effect

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doi: 10.2337/diabetes.55.02.06.db05-0885 100 MalikRAWilliamsonSAbbottCCarringtonALIqbalJSChadyWet al

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Regardless of whether the underlying etiology of endothelial imbalance is decreased levels of NO generation or enhancement of NO consumption, it has led to the investigation of numerous therapies to assess the reversibility of endothelial dysfunction by NO supplementation and the enhancement of the release of NO from the endothelium