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*Correspondence: Kun Chen, [email protected] This article was submitted to Cell Death and Survival, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Neuron 39(6):889909 Lees AJ, Hardy J, Revesz T (2009) Parkinsons disease Lancet Lond Engl 373:20552066 Graham JM, Paley MN, Grnewald RA, Hoggard N, Griffiths PD (2000) Brain iron deposition in Parkinsons disease imaged using the PRIME magnetic resonance sequence

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There are no physiologic mechanisms to eliminate excess iron from the body 1, 3, 4 Maintaining homeostatic balance requires only 1 to 2 mg of absorbed iron per day (i.e