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Further studies are still required before gene therapy is considered a first line treatment for Beta-thalassemia major

[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Pastore A., Federici G., Bertini E., Piemonte F

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In vitro studies in N2a cells showed that ApoE4 fragments (aa 1272) interact with mitochondria and cause mitochondrial dysfunction and neurotoxicity (Chang et al., 2005)

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