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CA IX directly participates in these hallmarks, as supported by the fact that its suppression, mutation/deletion, pharmacologic inhibition, or treatment with monoclonal antibodies result in significantly reduced growth of tumor xenografts in vivo [48, 6164]

J Neurophysiol 29: 788806, 1966

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The DOCA-salt model is relevant to human hypertension as it involves an hypervolemia, an activation of the sympathetic nervous system and the suppression of the peripheral RAAS system, and thus a low renin hypertension, which is observed in ~32 % of the hypertensive population (422)
