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It is also important to consider the fact that the bioavailability of L-carnitine and acylcarnitine derivatives administered orally is low (~10-20%) (see Metabolism and Bioavailability)

Similarly, in the present study, L-carnitine supplementation significantly increased the expression of CPT1, accompanied by decreasing and increasing the mRNA expression of TNF- and the anti-inflammatory factor TGF-1, respectively, in zebrafish muscle

Drugs that inhibit the carnitine shuttle cause fatty liver

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doi: 10.1111/j.1582-4934.2008.00390.x

Cell Physiol