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Intestinal epithelial cells also express most TLRs and both NODs, among which TLR2 and TLR4 signaling may influence the integrity of TJ complexes

Essentially, this system entails an upregulation of pro-inflammatory cytokines (like IL-6 and TNF-) and a downregulation of anti-inflammatory cytokines (like IL-10) [146]

In addition to TMA, a number of other glomerular lesions have been reported in patients but at a less frequent rate (for review see [69])

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Pituitary primordia were explanted from 11-day-old rat fetuses and cultured in a synthetic medium enriched with either DSIP at several concentrations, GnRH (10(-9) M) or TRH (10(-9) M)