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When a functional thyroid tumor is present, the abnormal thyroid tissue continues to produce thyroid hormones independent of this negative feedback mechanism

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Biotechniques 47 , 867869 (2009)
Thus, ASD is characterized by an imbalance of the processes of mitochondrial fusion, fission, and mitophagy that leads to contamination of the brain with dysfunctional mitochondrial fragments, insufficient energy supply to the brain tissues, and as a result, impairments of memory and synaptic function [187] contributing to ASD pathogenesis
