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Activation helps clear misfolded proteins and induce beneficial autophagy

VaccarinoVShahAJMehtaPKPearceBRaggiPBremnerJDet alBrain-heart connections in stress and cardiovascular disease: implications for the cardiac patient

10.1371/journal.pntd.0011498 187 PlanasG

Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death

Dietary antioxidants can neutralize ROS (Figure 2), particularly those that damage mitochondria, thereby reducing the accumulation of mitochondrial damage and the risk of cognitive dysfunction [98]

Subsequently, a postmortem human brain tissue study showed increased NADPH production in the putamen, cortex, and cerebellum of late-stage PD cases, while G6PD was decreased in the putamen of early-stage PD and in the cerebellum of early and late-stage PD