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Concomitant cagrilintide and semaglutide 2.4 mg for weight management: a randomised, controlled, phase 1b trial

Nat Metab 2 , 11861187 (2020)

Concentration Math Insulin Syringe Units (U-100, 100 units = 1 mL) Yield at maintenance: at a 1.2 mg combined dose per week, the vial provides ~3 weeks of dosing (15 mg 1.2 mg/wk = 12.5 weeks at total mass, but draws of 16 units twice a week or 16 units once a week land at ~3 weeks of practical use given common dosing patterns)

For a while this will mean that the person does not appear to be B12 deficient, but eventually as levels drop far enough the person will experience adrenal fatigue and symptoms of melatonin deficiency, such as an inability to sleep

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