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Since decreased Parasutterella relative abundance may accompany increased stress 80,81 , the increased Parasutterella relative abundance that occurred in this study following diet switch likely arose from the weight loss-mediated negative energy state

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The most abundant genus was Ileibacterium , a relatively novel genus of the Firmicutes phylum 48

These comparative safety differences make AOD-9604 potentially suitable for individuals who might not tolerate full growth hormone therapy or who have contraindications to traditional GH use

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