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Low tumor oxygen and low blood oxygen enhance tumor growth and create resistance to treatment as described in the section The Five Rs of Radiobiology (Gaspar 2015)

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10.1126/science.182.4115.929

and Maureen Lyons for help with sequencing of the CRISPR library

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In contrast, using targeted treatments for Fusobacterium , such as metronidazole or berberine, would be the recommended root cause approach
