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Tier 2 for modified or stabilized peptides with added toxicology, pharmacokinetics, and limited human safety studies
[DOI] [PubMed] [Google Scholar] 182.Cook TM, Mansuy-Aubert V

Preclinical research has examined its role in promoting angiogenesis, reducing oxidative stress in intestinal tissue, and interacting with the nitric oxide system to modulate gut blood flow

In lung cancer cells, an HSC70/CMA-driven decrease in GPX4 levels is also observed

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