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10.1016/j.cmet.2014.04.005 216

11 In islet alpha-cells, prohormone convertase 2 modifies proglucagon to produce glucagon, which is formed by the removal of aa residues adjacent to 33 and 61 of proglucagon

Thats roughly the same as the one-off cost of bariatric surgery

These findings were confirmed in high-fat, high-cholesterol (HFHC) dietfed mice with functional LDL receptor deficiency induced by viral expression of proprotein convertase subtilisin/kexin type 9adeno-associated virus (PCSK9-AAV), in which daily administration of semaglutide for 18 weeks reduced aortic plaque area (11)

Philips is now returning, which will introduce some competitive pressure, but ResMed used that window to entrench its position: investing in cloud-connected devices, AI-powered comfort settings trained on more than 100 million nights of sleep data, and remote monitoring platforms that allow doctors to manage patients without office visits