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Genes (Basel) 8 Prickaerts P, Adriaens ME, van den Beucken T, Koch E, Dubois L, Dahlmans VEH, Gits C, Evelo CTA, Chan-Seng-Yue M, Wouters BG et al (2016) Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3

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Problems with memory Shortness of breath and weakness Problems with coordination and balance When a b12 vitamin deficiency is suspected, supplements can be given either in the form of oral pill, sublingual lozenges, or vitamin B12 injections also known as B12 shots

The actin-binding protein synaptopodin modulates synaptic activity of cortical and hippocampal neurons by promoting formation of dendritic spines and regulating local Ca 2+ levels, processes in which mitochondria are critical 51,52