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Free Radic Biol Med 75:156166 Chang MCJ, Grieder FB (2024) The continued importance of animals in biomedical research

Pediatric Use: Pediatric patients' safety and efficacy have not been shown

reported that PMX53, a C5a receptor 1 (C5aR-1) antagonist, mitigated hepatic IRI through inhibiting pro-inflammatory cytokine release and neutrophil/macrophage infiltration and platelet aggregation (Kusakabe et al., 2020), suggesting the crosstalk between coagulation and complement system

Medications: Certain medications, such as proton pump inhibitors (PPIs) and metformin, can interfere with B12 absorption

Dexmedetomidine attenuates ferroptosis-mediated renal ischemia/reperfusion injury and inflammation by inhibiting ACSL4 via 2-AR

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