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Because cysteine is often the scarcest of the three amino acids needed to make glutathione, NAC acts as a "rate-limiting" precursor

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Heavy Metal Exposure Humans are exposed to various heavy metals from food, water, and the environment (1, 2): Mercury from seafood, high-fructose corn syrup, rice, and beauty products Arsenic from soil, crops, water, fertilizer, and tobacco Cadmium from batteries, plastic stabilizers, vegetables, chocolate, and cigarettes Lead from soil, house paint, smoking, and batteries Antimony from food, water, coal, and medicine Tungsten from industrial sources, water, and food Heavy metals are distributed to almost all tissues

4c, d, Fig

B12 is one important piece, but persistent exhaustion usually has more than one contributing factor

In addition, Zhao et al