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Warnings & Precautions: Black box warning: Risk of thyroid C-cell tumors observed in rodents

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The fact that the IOM did not establish an upper level (UL) at the time, since, as the institute stated, it cannot be determined due to a lack of data on adverse effects, does not mean that there are none

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In addition, a wide range of studies have shown that NNMT is elevated in various cancers, including squamous cell carcinoma (SCC) (27), colorectal cancer (12), renal cell carcinoma (28), bladder cancer (29), ovarian cancer (30), cutaneous malignant melanoma (CMM) (31), gastric cancer (32), pancreatic cancer (33, 34), and glioblastoma (GBM) (7)

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