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At week 12, levels of symmetric dimethylarginine and blood urea nitrogen were found to be significantly higher in the test group compared with the control group ( P 003)

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This formulation showed improved skin dispersion, resulting in a twofold increase, and decreased release of inflammatory markers such as IL-4 and IL-5 by TH2 cells when tested in a mouse model of AD [82]

Clinical data demonstrates that gastrointestinal side effects follow a predictable pattern of being most prominent during treatment initiation and dose escalation periods, then declining substantially as the body adapts